Search results for "Lī sindroms"

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Ar Lī sindromu saistīto mitohondriālās DNS variantu ietekme uz gēnu ekspresiju

2022

Lī sindroms ir reta iedzimta progresējoša neirodeģeneratīva mitohondriālā slimība, kas parasti sāk izpausties jau zīdaiņa vecumā vai agrā bērnībā. Lī sindromu var izraisīt izmaiņas gan kodola, gan mitohondriju genomā. Patogēni varianti mitohondriju genomā var ietekmēt kodola gēnu ekspresiju caur mitohondriju atgriezenisko regulāciju. Maģistra darba mērķis bija noskaidrot divu, ar Lī sindromu saistītu, mitohondriālās DNS (mtDNS) variantu ietekmi uz gēnu ekspresiju. Tika veikta transkriptoma analīze transmitohondriālo citoplazmatisko hibrīdu (cibrīdu) šūnu līnijām, kas saturēja divus ar Lī sindromu saistītus mtDNS variantus, pārbaudīta abu patogēno variantu heteroplazmijas stabilitāte, veikta…

Mitohondriālā DNSLī sindromsgēnu ekspresijaBioloģijamitohondriju atgriezeniskā regulācija

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PEPhysical Sciences and Engineering
- PE2Fundamental Constituents of Matter
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LSLife Sciences
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- LS2Integrative Biology: from Genes and Genomes to Systems
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